USC president C. L. Max Nikias and National Academy of Engineering president Chuck Vest addressed hundreds of America’s leading engineers, scientists, educators, innovators, policy leaders and corporate executives at the second annual NAE Grand Challenges National Summit, which was held at USC Oct. 6 to 8, 2010. This year’s summit was a forum for the country’s top minds to share their ideas about solving the 14 Grand Challenges first articulated by the NAE in 2008.